Vascular Events in COVID-19
 

The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection – Neurologists Move to the Frontlines; Samuel J. Pleasure, MD, PhD; Ari J. Green, MD; S. Andrew Josephson; JAMA Neurol. Published online April 10, 2020. DOI: 10.1001/jamaneurol.2020.1065 https://jamanetwork.com/journals/jamaneurology/fullarticle/2764548; Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco.

Endothelial cell infection and endotheliitis in COVID-19; Zsuzsanna Varga; Andreas J Flammer; Peter Steiger; Martina Haberecker; Rea Andermatt; Annelies S. Zinkernagel et al. Published: April 20, 2020; DOI: 10.1016/S0140-6736(20)30937-5 https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(20)30937-5.pdf

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation; Safiya Richardson, MD, MPH1,2; Jamie S. Hirsch, MD, MA, MSB1,2,3; Mangala Narasimhan, Published online April 28, 2020. https://link.springer.com/article/10.1007%2Fs00134-020-06059-6

Incidence of thrombotic complications in critically ill ICU patients with COVID-19; F.A. Kloka, M.J.H.A. Kruipb, N.J.M. van der Meerc, M.S. Arbousd, D.A.M.P.J. Gommerse K.M. Kantf, F.H.J. Kapteina, J. van Paassend, M.A.M. Stalsa, M.V. Huismana,1, H. Endeman, DOI: 10.1016/j.thromres.2020.04.013  © 2020 Published by Elsevier Ltd https://www.thrombosisresearch.com/article/S0049-3848(20)30120-1/pdf

Acute ischemic stroke with COVID-19: an international consensus statement; Qureshi AI & al. Int J Stroke 03.05.2020 https://www.univadis.de/viewarticle/acute-ischemic-stroke-with-covid-19-an-international-consensus-statement-719799

COVID-19-Related Stroke; David C. Hess; Wael Eldahshan; Elizabeth Rutkowski; Translational Stroke Research; DOI: 10.1007/s12975-020-00818-9; 06.05.2020 https://link.springer.com/article/10.1007/s12975-020-00818-9
 
Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area; Safiya Richardson, MD, MPH; Jamie S. Hirsch, MD, MA, MSB; Mangala Narasimhan, DO; JAMA. Published online April 22, 2020. DOI:10.1001/jama.2020.6775; https://jamanetwork.com/journals/jama/fullarticle/2765184

Severe COVID-19 infection associated with endothelial activation; Robert Eschera, Neal Breakeya, Bernhard Lämmle; Letter to the Editors-in-Chief|
Volume 190, P62, June 01, 2020

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis; Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S., Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1377-84. DOI: 10.1152/ajpheart.00331.2008. Epub 2008 Jul 25.
 
COVID-19 and Oxidative Stress (Prevention & Risk Factors)
 

Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic; Eakachai Prompetchara, Chutitorn Ketloy, Tanapat Palaga; Asian Pac J Allergy Immunol 2020;38:1-9 DOI: 10.12932/AP-200220-0772; https://journals.physiology.org/doi/full/10.1152/ajpheart.00331.2008

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis; Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S., Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1377-84. DOI: 10.1152/ajpheart.00331.2008. Epub 2008 Jul 25. https://journals.physiology.org/doi/full/10.1152/ajpheart.00331.2008

ACE2 and Ang-(1–7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response;
Zhang YH, Zhang YH, Dong XF, Hao QQ, Zhou XM, Yu QT, Li SY, Chen X, Tengbeh AF, Dong B, Zhang Y.; Inflamm Res. 2015 Apr;64(3-4):253-60. DOI: 10.1007/s00011-015-0805-1 Epub 2015 Feb 27; Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia. Stanhewicz AE, Alexander LM; Am J Physiol Regul Integr Comp Physiol. 2020 Jan 1;318(1):R148-R155. DOI: 10.1152/ajpregu.00221.2019. Epub 2019 Oct 2 Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania. https://pennstate.pure.elsevier.com/en/publications/local-angiotensin-17-administration-improves-microvascular-endoth

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area; Safiya Richardson, MD, MPH; Jamie S. Hirsch, MD, MA, MSB; Mangala Narasimhan, DO; JAMA. Published online April 22, 2020. DOI:10.1001/jama.2020.6775; https://jamanetwork.com/journals/jama/fullarticle/2765184

Nutrients and Oxidative Stress: Friend or Foe? Bee Ling Tan,Mohd Esa Norhaizan and Winnie-Pui-Pui LiewOxidative Medicine and Cellular LongevityVolume 2018, Article ID 9719584, 24 pages; DOI: 10.1155/2018/9719584; https://www.researchgate.net/publication/322852493_Nutrients_and_Oxidative_Stress_Friend_or_Foe

Oxidative stress in endothelial cell dysfunction and thrombosis; Joseph Loscalzo, M.D., Ph.D.; Pathophysiol Haemost Thromb 2002;32:359–360; DOI: 10.1159/000073600;

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis; Lovren F1, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S., Am J Physiol Heart Circ Physiol. 2008 Oct;295(4): H1377-84. DOI: 10.1152/ajpheart.00331.2008. Epub 2008 Jul 25.; https://journals.physiology.org/doi/full/10.1152/ajpheart.00331.2008

Quellen

Prof. F. Ruschitzka, Direktor der Kardiologie an der Zürcher Klinik
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext

Prof. Dr. Götz Thomalla, Hamburg, Sprecher der DGN-Kommission Zerebrovaskuläre Erkrankungen Prof. Peter Berlit, Generalsekretär der Deutschen Gesellschaft für Neurologie (DGN))
https://www.mta-dialog.de/artikel/ist-sars-cov-2-ein-schlaganfallausloeser.html

Prof. Klaus Püschel, Direktor am Institut für Rechtsmedizin des Universitätsklinikums Hamburg-Eppendorf (UKE)
https://www.acpjournals.org/aim/fullarticle/2765934/autopsy-findings-venous-thromboembolism-patients-covid-19-prospective-cohort-study
Wichmann D et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med. 06.05.2020

Roger D. Seheult, MD, Pulmologe, Banning Specialty Care Center, California, USA
Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://www.youtube.com/watch?v=22Bn8jsGI54
Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors) https://www.youtube.com/watch?v=gzx8LH4Fjic

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China Ling Mao; Huijuan Jin; Mengdie Wang; et al Yu Hu; Shengcai Chen; Quanwei He; Jiang Chang; Candong Hong; Yifan Zhou; David Wang; Xiaoping Miao; Yanan Li, MD, PhD; Bo Hu, MD, PhD JAMA Neurol. published online April 10, 2020. doi:10.1001/jamaneurol.2020.1127 JAMA Neurol. published online April 10, 2020. doi:10.1001/jamaneurol.2020.1127